Efficient Gene Delivery and Expression in Pancreas and Pancreatic Tumors by Capsid-Optimized AAV8 Vectors

Despite efforts to use adeno-associated viral (AAV) vector–mediated gene therapy for treatment of pancreatic ductal adenocarcinoma (PDAC), transduction efficiency remains a limiting factor and thus improvement of AAV delivery would significantly facilitate the treatment of this malignancy. Site-dire...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther Methods
Main Authors: Chen, Min, Maeng, Kyungah, Nawab, Akbar, Francois, Rony A., Bray, Julie K., Reinhard, Mary K., Boye, Sanford L., Hauswirth, William W., Kaye, Frederic J., Aslanidi, Georgiy, Srivastava, Arun, Zajac-Kaye, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Special Issue on Adeno-Associated Viral (AAV) Vectors:Production, Purification, and Beyond—Part 1Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314986/
https://ncbi.nlm.nih.gov/pubmed/28125909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2016.089
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