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Activation of the Mechanistic Target of Rapamycin in SLE: Explosion of Evidence in the Last Five Years

The mechanistic target of rapamycin (mTOR) is a central regulator in cell growth, activation, proliferation, and survival. Activation of the mTOR pathway underlies the pathogenesis of systemic lupus erythematosus (SLE). While mTOR activation and its therapeutic reversal were originally discovered in...

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Pubblicato in:Curr Rheumatol Rep
Autori principali: Oaks, Zachary, Winans, Thomas, Huang, Nick, Banki, Katalin, Perl, Andras
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314949/
https://ncbi.nlm.nih.gov/pubmed/27812954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11926-016-0622-8
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