Mitochondrial Dysfunction in the Liver and Antiphospholipid Antibody Production Precede Disease Onset and Respond to Rapamycin in Lupus‐Prone Mice

OBJECTIVE: Antiphospholipid antibodies (aPL) constitute a diagnostic criterion of systemic lupus erythematosus (SLE), and aPL have been functionally linked to liver disease in patients with SLE. Since the mechanistic target of rapamycin (mTOR) is a regulator of oxidative stress, a pathophysiologic p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arthritis Rheumatol
Prif Awduron: Oaks, Zachary, Winans, Thomas, Caza, Tiffany, Fernandez, David, Liu, Yuxin, Landas, Steve K., Banki, Katalin, Perl, Andras
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Systemic Lupus Erythematosus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5083168/
https://ncbi.nlm.nih.gov/pubmed/27332042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39791
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