Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7

The KEOPS/EKC complex is a tRNA modification complex involved in the biosynthesis of N(6)-threonylcarbamoyladenosine (t(6)A), a universally conserved tRNA modification found on ANN-codon recognizing tRNAs. In archaea and eukaryotes, KEOPS is composed of OSGEP/Kae1, PRPK/Bud32, TPRKB/Cgi121 and LAGE3...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Wan, Leo C.K., Maisonneuve, Pierre, Szilard, Rachel K., Lambert, Jean-Philippe, Ng, Timothy F., Manczyk, Noah, Huang, Hao, Laister, Rob, Caudy, Amy A., Gingras, Anne-Claude, Durocher, Daniel, Sicheri, Frank
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314774/
https://ncbi.nlm.nih.gov/pubmed/27903914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1181
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