Lysophosphatidic acid signaling through its receptor initiates pro-fibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor

The expansion of the fibroblast pool is a critical step in organ fibrosis, but the mechanisms driving expansion remain to be fully clarified. We previously showed that lysophosphatidic acid (LPA) signaling through its receptor LPA(1) expressed on fibroblasts directly induces the recruitment of these...

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Publicado en:Kidney Int
Autores principales: Sakai, Norihiko, Chun, Jerold, Duffield, Jeremy S., Lagares, David, Wada, Takashi, Luster, Andrew D., Tager, Andrew M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313343/
https://ncbi.nlm.nih.gov/pubmed/27927603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2016.09.030
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