Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force

Selectin interactions with fucosylated glycan ligands mediate leukocyte rolling in the vasculature under shear forces. Crystal structures of P- and E-selectin suggest a two-state model in which ligand binding to the lectin domain closes loop 83–89 around the Ca(2+) coordination site, enabling Glu-88...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Mehta-D'souza, Padmaja, Klopocki, Arkadiusz G., Oganesyan, Vaheh, Terzyan, Simon, Mather, Timothy, Li, Zhenhai, Panicker, Sumith R., Zhu, Cheng, McEver, Rodger P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Glycobiology and Extracellular Matrices
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313117/
https://ncbi.nlm.nih.gov/pubmed/28011641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.767186
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