The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process

Oligomerization of the mixed-lineage kinase domain-like protein (MLKL) is essential for its cation channel function in necroptosis. Here we show that the MLKL channel is an octamer comprising two previously identified tetramers most likely in their side-by-side position. Intermolecule disulfide bond...

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Vydáno v:Mol Cell Biol
Hlavní autoři: Huang, Deli, Zheng, Xinru, Wang, Zi-an, Chen, Xin, He, Wan-ting, Zhang, Yingying, Xu, Jin-Gen, Zhao, Hang, Shi, Wenke, Wang, Xin, Zhu, Yongqun, Han, Jiahuai
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5311246/
https://ncbi.nlm.nih.gov/pubmed/27920255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00497-16
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