The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process

Oligomerization of the mixed-lineage kinase domain-like protein (MLKL) is essential for its cation channel function in necroptosis. Here we show that the MLKL channel is an octamer comprising two previously identified tetramers most likely in their side-by-side position. Intermolecule disulfide bond...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Huang, Deli, Zheng, Xinru, Wang, Zi-an, Chen, Xin, He, Wan-ting, Zhang, Yingying, Xu, Jin-Gen, Zhao, Hang, Shi, Wenke, Wang, Xin, Zhu, Yongqun, Han, Jiahuai
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5311246/
https://ncbi.nlm.nih.gov/pubmed/27920255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00497-16
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