The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process

Oligomerization of the mixed-lineage kinase domain-like protein (MLKL) is essential for its cation channel function in necroptosis. Here we show that the MLKL channel is an octamer comprising two previously identified tetramers most likely in their side-by-side position. Intermolecule disulfide bond...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Huang, Deli, Zheng, Xinru, Wang, Zi-an, Chen, Xin, He, Wan-ting, Zhang, Yingying, Xu, Jin-Gen, Zhao, Hang, Shi, Wenke, Wang, Xin, Zhu, Yongqun, Han, Jiahuai
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5311246/
https://ncbi.nlm.nih.gov/pubmed/27920255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00497-16
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge