Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor

The epithelial mesenchymal transition (EMT) promotes tumor migration and invasion by downregulating epithelial markers such as E-cadherin and upregulating mesenchymal markers such as vimentin. Cathepsin L (Cat L) is a cysteine protease that can proteolytically activate CCAAT displacement protein/cut...

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Опубликовано в: :Mol Cell Biol
Главные авторы: Burton, Liza J., Dougan, Jodi, Jones, Jasmine, Smith, Bethany N., Randle, Diandra, Henderson, Veronica, Odero-Marah, Valerie A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2017
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5311241/
https://ncbi.nlm.nih.gov/pubmed/27956696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00297-16
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