Mildly Acidic pH Triggers an Irreversible Conformational Change in the Fusion Domain of Herpes Simplex Virus 1 Glycoprotein B and Inactivation of Viral Entry

Herpes simplex virus (HSV) entry into a subset of cells requires endocytosis and endosomal low pH. Preexposure of isolated virions to mildly acidic pH of 5 to 6 partially inactivates HSV infectivity in an irreversible manner. Acid inactivation is a hallmark of viruses that enter via low-pH pathways;...

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Vydáno v:J Virol
Hlavní autoři: Weed, Darin J., Pritchard, Suzanne M., Gonzalez, Floricel, Aguilar, Hector C., Nicola, Anthony V.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309949/
https://ncbi.nlm.nih.gov/pubmed/28003487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02123-16
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