A Genome-wide Approach Validates that Thiopurine Methyltransferase Activity is a Monogenic Pharmacogenomic Trait

We performed a genome-wide association study of primary erythrocyte TPMT activity in children with leukemia (n = 1026). Adjusting for age and ancestry, TPMT was the only gene that reached genome-wide significance (top hit rs1142345 or 719A>G, P = 8.6 × 10(−61)). Additional genetic variants (besid...

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Bibliografiske detaljer
Udgivet i:Clin Pharmacol Ther
Main Authors: Liu, Chengcheng, Yang, Wenjian, Pei, Deqing, Cheng, Cheng, Smith, Colton, Landier, Wendy, Hageman, Lindsey, Chen, Yanjun, Yang, Jun J., Crews, Kristine R., Kornegay, Nancy, Karol, Seth E., Wong, F. Lennie, Jeha, Sima, Sandlund, John T., Ribeiro, Raul R., Rubnitz, Jeffrey E., Metzger, Monika L., Pui, Ching-Hon, Evans, William E., Bhatia, Smita, Relling, Mary V.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309133/
https://ncbi.nlm.nih.gov/pubmed/27564568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.463
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