Mutational profiling of non-small-cell lung cancer patients resistant to first-generation EGFR tyrosine kinase inhibitors using next generation sequencing

Patients with advanced non-small-cell lung cancer (NSCLC) harboring sensitive epithelial growth factor receptor (EGFR) mutations invariably develop acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). Identification of actionable genetic alterations conferring drug-resistance can be helpfu...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Jin, Ying, Shao, Yang, Shi, Xun, Lou, Guangyuan, Zhang, Yiping, Wu, Xue, Tong, Xiaoling, Yu, Xinmin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308688/
https://ncbi.nlm.nih.gov/pubmed/27528220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11237
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