Lysosome-associated membrane glycoprotein 1 predicts fratricide amongst T cell receptor transgenic CD8(+) T cells directed against tumor-associated antigens

AIM: Autologous as well as allogeneic CD8(+) T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive transfer. Besides unpredictable life-threatening off-target effects, these TCRs may unexpectedly commit fratricide. We hypothesized lysos...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kirschner, Andreas, Thiede, Melanie, Blaeschke, Franziska, Richter, Günther H.S., Gerke, Julia S., Baldauf, Michaela C., Grünewald, Thomas G.P., Busch, Dirk H., Burdach, Stefan, Thiel, Uwe
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302936/
https://ncbi.nlm.nih.gov/pubmed/27447745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10647
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