Pappalysin-1 T cell receptor transgenic allo-restricted T cells kill Ewing sarcoma in vitro and in vivo

Pregnancy-associated plasma protein-A (PAPPA), also known as pappalysin, is a member of the insulin-like growth factor (IGF) family. PAPPA acts as a protease, cleaving IGF inhibitors, i.e., IGF binding proteins (IGFBPs), thereby setting free IGFs. The insulin/IGF-axis is involved in cancer in genera...

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Publicat a:Oncoimmunology
Autors principals: Kirschner, Andreas, Thiede, Melanie, Grünewald, Thomas G. P., Alba Rubio, Rebeca, Richter, Günther H. S., Kirchner, Thomas, Busch, Dirk H., Burdach, Stefan, Thiel, Uwe
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2017
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353903/
https://ncbi.nlm.nih.gov/pubmed/28344885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1273301
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