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Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation
Human CD34+ hematopoietic stem and progenitor cells (HSPC) expressing fusion protein AML1-ETO (AE), generated by the t(8;21)(q22;q22) rearrangement, manifest enhanced self-renewal and dysregulated differentiation without leukemic transformation, representing a pre-leukemia stage. Enabling replicativ...
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| Publicado en: | Oncotarget |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5302887/ https://ncbi.nlm.nih.gov/pubmed/27509060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11093 |
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