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Use of exogenous hTERT to immortalize primary human cells
A major obstacle to the immortalization of primary human cells and the establishment of human cell lines is telomere-controlled senescence. Telomere-controlled senescence is caused by the shortening of telomeres that occurs each time somatic human cells divide. The enzyme telomerase can prevent the...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Kluwer Academic Publishers
2004
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3449956/ https://ncbi.nlm.nih.gov/pubmed/19003241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/10.1007/s10616-004-5123-3 |
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