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CENP-A chromatin disassembly in stressed and senescent murine cells

Centromeres are chromosomal domains essential for genomic stability. We report here the remarkable transcriptional and epigenetic perturbations at murine centromeres in genotoxic stress conditions. A strong and selective transcriptional activation of centromeric repeats is detected within hours. Thi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hédouin, Sabrine, Grillo, Giacomo, Ivkovic, Ivana, Velasco, Guillaume, Francastel, Claire
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5301216/
https://ncbi.nlm.nih.gov/pubmed/28186195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42520
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