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CENP-A chromatin disassembly in stressed and senescent murine cells

Centromeres are chromosomal domains essential for genomic stability. We report here the remarkable transcriptional and epigenetic perturbations at murine centromeres in genotoxic stress conditions. A strong and selective transcriptional activation of centromeric repeats is detected within hours. Thi...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Hédouin, Sabrine, Grillo, Giacomo, Ivkovic, Ivana, Velasco, Guillaume, Francastel, Claire
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5301216/
https://ncbi.nlm.nih.gov/pubmed/28186195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42520
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