Dopamine-Induced Changes in Gα(olf) Protein Levels in Striatonigral and Striatopallidal Medium Spiny Neurons Underlie the Genesis of l-DOPA-Induced Dyskinesia in Parkinsonian Mice

The dopamine precursor, l-3,4-dihydroxyphenylalanine (l-DOPA), exerts powerful therapeutic effects but eventually generates l-DOPA-induced dyskinesia (LID) in patients with Parkinson’s disease (PD). LID has a close link with deregulation of striatal dopamine/cAMP signaling, which is integrated by me...

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Bibliographic Details
Published in:Front Cell Neurosci
Main Authors: Morigaki, Ryoma, Okita, Shinya, Goto, Satoshi
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5300978/
https://ncbi.nlm.nih.gov/pubmed/28239340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2017.00026
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