Hedgehog signaling in bone regulates whole-body energy metabolism through a bone–adipose endocrine relay mediated by PTHrP and adiponectin

Bone plays a role in energy metabolism, but the interplay between bone and other organs in this process is not completely understood. Here, we show that upregulated Hh signaling in bones results in increased whole-body energy expenditure, white adipose tissue (WAT) browning, hypoglycemia and skeleta...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Zhang, Xu, Cheng, Qianni, Wang, Yixiang, Leung, Po Sing, Mak, Kinglun Kingston
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299706/
https://ncbi.nlm.nih.gov/pubmed/27740628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.113
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