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Hedgehog signaling in bone regulates whole-body energy metabolism through a bone–adipose endocrine relay mediated by PTHrP and adiponectin

Bone plays a role in energy metabolism, but the interplay between bone and other organs in this process is not completely understood. Here, we show that upregulated Hh signaling in bones results in increased whole-body energy expenditure, white adipose tissue (WAT) browning, hypoglycemia and skeleta...

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Bibliografski detalji
Izdano u:Cell Death Differ
Glavni autori: Zhang, Xu, Cheng, Qianni, Wang, Yixiang, Leung, Po Sing, Mak, Kinglun Kingston
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299706/
https://ncbi.nlm.nih.gov/pubmed/27740628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.113
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