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The Wnt/β-Catenin Pathway Interacts Differentially with PTHrP Signaling to Control Chondrocyte Hypertrophy and Final Maturation

Sequential proliferation, hypertrophy and maturation of chondrocytes are required for proper endochondral bone development and tightly regulated by cell signaling. The canonical Wnt signaling pathway acts through β-catenin to promote chondrocyte hypertrophy whereas PTHrP signaling inhibits it by hol...

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Detalles Bibliográficos
Main Authors: Guo, Xizhi, Mak, Kinglun Kingston, Taketo, Makoto M., Yang, Yingzi
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698152/
https://ncbi.nlm.nih.gov/pubmed/19557172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006067
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