Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation

BACKGROUND: Brain-derived neurotrophic factor (BDNF) exerts beneficial effects not only on diabetic neuropathies but also on cardiovascular injury. There is argument regarding the levels of serum BDNF in patients with diabetes mellitus (DM). Because BDNF in peripheral blood is rich in platelets, thi...

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Bibliographic Details
Published in:Cardiovasc Diabetol
Main Authors: Furukawa, Kazuo, Fuse, Ichiro, Iwakura, Yuriko, Sotoyama, Hidekazu, Hanyu, Osamu, Nawa, Hiroyuki, Sone, Hirohito, Takei, Nobuyuki
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
Subjects:
Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299653/
https://ncbi.nlm.nih.gov/pubmed/28178976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-017-0505-y
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