Insertion of scFv into the hinge domain of full-length IgG1 monoclonal antibody results in tetravalent bispecific molecule with robust properties

By simultaneous binding two disease mediators, bispecific antibodies offer the opportunity to broaden the utility of antibody-based therapies. Herein, we describe the design and characterization of Bs4Ab, an innovative and generic bispecific tetravalent antibody platform. The Bs4Ab format comprises...

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Publicado en:MAbs
Main Authors: Bezabeh, Binyam, Fleming, Ryan, Fazenbaker, Christine, Zhong, Haihong, Coffman, Karen, Yu, Xiang-Qing, Leow, Ching Ching, Gibson, Nerea, Wilson, Susan, Stover, C. Kendall, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2016
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Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297521/
https://ncbi.nlm.nih.gov/pubmed/27981887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1270492
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