AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N(6)-methyladenosine

Skeletal muscle plays important roles in whole-body energy homeostasis. Excessive skeletal muscle lipid accumulation is associated with some metabolic diseases such as obesity and Type 2 Diabetes. The energy sensor AMPK (AMP-activated protein kinase) is a key regulator of skeletal muscle lipid metab...

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Vydáno v:Sci Rep
Hlavní autoři: Wu, Weiche, Feng, Jie, Jiang, Denghu, Zhou, Xihong, Jiang, Qin, Cai, Min, Wang, Xinxia, Shan, Tizhong, Wang, Yizhen
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296945/
https://ncbi.nlm.nih.gov/pubmed/28176824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41606
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