GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m(6)A on lipogenic mRNAs

Chronic stress or excessive exposure to glucocorticoids (GC) contributes to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Glucocorticoid receptor (GR) mediates the action of GC, but its downstream signalling is not fully understood. Fat mass and obesity associated (FTO) protein and...

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Detalhes bibliográficos
Publicado no:RNA Biol
Main Authors: Hu, Yun, Feng, Yue, Zhang, Luchu, Jia, Yimin, Cai, Demin, Qian, Shu-Bing, Du, Min, Zhao, Ruqian
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549648/
https://ncbi.nlm.nih.gov/pubmed/32116145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2020.1736868
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