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N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment
N,N-Dimethylacetamide (DMA) is a water-miscible solvent, FDA approved as excipient and therefore widely used as drug-delivery vehicle. As such, DMA should be devoid of any bioactivity. Here we report that DMA is epigenetically active since it binds bromodomains and inhibits osteoclastogenesis and in...
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| Vydáno v: | Sci Rep |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5296751/ https://ncbi.nlm.nih.gov/pubmed/28176838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42108 |
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