Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals

Centrosome amplification is a common feature of human tumors, but whether this is a cause or a consequence of cancer remains unclear. Here, we test the consequence of centrosome amplification by creating mice in which centrosome number can be chronically increased in the absence of additional geneti...

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Veröffentlicht in:Dev Cell
Hauptverfasser: Levine, Michelle S., Bakker, Bjorn, Boeckx, Bram, Moyett, Julia, Lu, James, Vitre, Benjamin, Spierings, Diana C., Lansdorp, Peter M., Cleveland, Don W., Lambrechts, Diether, Foijer, Floris, Holland, Andrew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296221/
https://ncbi.nlm.nih.gov/pubmed/28132847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2016.12.022
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