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Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B
APOBEC-catalyzed cytosine-to-uracil deamination of single-stranded (ss)DNA has beneficial functions in immunity and detrimental roles in cancer. APOBEC enzymes have intrinsic dinucleotide specificities that impart hallmark mutation signatures. Despite numerous structures, mechanisms for global ssDNA...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5296220/ https://ncbi.nlm.nih.gov/pubmed/27991903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3344 |
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