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TGF-β1-mediated Smad3 enhances PD-1 expression on antigen-specific T cells in cancer
Programmed Death-1 (PD-1) is a co-inhibitory receptor that down-regulates the activity of tumor-infiltrating lymphocytes (TIL) in cancer and of virus-specific T cells in chronic infection. The molecular mechanisms driving high PD-1 expression on TIL have not been fully investigated. We demonstrate t...
में बचाया:
में प्रकाशित: | Cancer Discov |
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मुख्य लेखकों: | , , , , , , , , , , , , |
स्वरूप: | Artigo |
भाषा: | Inglês |
प्रकाशित: |
2016
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विषय: | |
ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5295786/ https://ncbi.nlm.nih.gov/pubmed/27683557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1347 |
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