TGF-β1-mediated Smad3 enhances PD-1 expression on antigen-specific T cells in cancer

Programmed Death-1 (PD-1) is a co-inhibitory receptor that down-regulates the activity of tumor-infiltrating lymphocytes (TIL) in cancer and of virus-specific T cells in chronic infection. The molecular mechanisms driving high PD-1 expression on TIL have not been fully investigated. We demonstrate t...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Park, Benjamin V., Freeman, Zachary T., Ghasemzadeh, Ali, Chattergoon, Michael A., Rutebemberwa, Alleluiah, Steigner, Jordana, Winter, Matthew E., Huynh, Thanh V., Sebald, Suzanne M., Lee, Se-Jin, Pan, Fan, Pardoll, Drew M., Cox, Andrea L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5295786/
https://ncbi.nlm.nih.gov/pubmed/27683557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1347
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