High Programmed Death-1 levels on HCV specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection

HCV is an important human pathogen that represents a model for chronic infection since the majority of infected individuals fail to clear the infection despite generation of virus-specific T cell responses during the period of acute infection. While viral sequence evolution at targeted MHC class I r...

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Main Authors: Rutebemberwa, Alleluiah, Ray, Stuart C., Astemborski, Jacquie, Levine, Jordana, Liu, Lin, Dowd, Kimberly A., Clute, Shalyn, Wang, Changyu, Korman, Alan, Sette, Alessandro, Sidney, John, Pardoll, Drew M., Cox, Andrea L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773824/
https://ncbi.nlm.nih.gov/pubmed/19050238
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