Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors

Since epidermal growth factor receptor (EGFR) is commonly deregulated in pre-malignant lung epithelium, targeting EGFR may arrest the development of lung cancer. Here, we showed that honokiol (2.5–7.5 μM), a bioactive compound of Magnolia officinalis, differentially suppressed proliferation (up to 9...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Song, Jung Min, Anandharaj, Arunkumar, Upadhyaya, Pramod, Kirtane, Ameya R., Kim, Jong-Hyuk, Hong, Kwon Ho, Panyam, Jayanth, Kassie, Fekadu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5295387/
https://ncbi.nlm.nih.gov/pubmed/27458163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10759
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