Non-toxic dose of liposomal honokiol suppresses metastasis of hepatocellular carcinoma through destabilizing EGFR and inhibiting the downstream pathways

At present, there is no specific anti-metastasis drug in HCC treatment. Drugs used for primary HCC tumors and tumor metastasis are very similar, among which cytotoxic drugs are prevalent, such as cisplatin, doxorubicin and 5-FU. The EGFR pathway plays an important role in promoting hepatocellular ca...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Yang, Jianhong, Pei, Heying, Luo, Hong, Fu, Afu, Yang, Hansuo, Hu, Jia, Zhao, Chengjian, Chai, LuLu, Chen, Xiang, Shao, Ximing, Wang, Chunyu, Wu, Wenshuang, Wan, Li, Ye, Haoyu, Qiu, Qiang, Peng, Aihua, Wei, Yuquan, Yang, Li, Chen, Lijuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352206/
https://ncbi.nlm.nih.gov/pubmed/27906672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13687
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