Millepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-κB pathway in ovarian cancer

Millepachine (MIL) was a novel chalcone that was separated from Millettia pachycarpa Benth (Leguminosae). We found MIL induced apoptosis through activating NF-κB pathway both in SK-OV-3 and A2780S cells. Western blot showed that MIL increased the levels of IKKα, p-IKKα/β, p-IκBα and NF-κB (p65) prot...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wu, Wenshuang, Ma, Buyun, Ye, Haoyu, Wang, Taijin, Wang, Xiaoyan, Yang, Jianhong, Wei, Yuquan, Zhu, Jingqiang, Chen, Lijuan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5239551/
https://ncbi.nlm.nih.gov/pubmed/27447570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10739
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