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Exploiting Nanotechnology to Overcome Tumor Drug Resistance: Challenges and Opportunities

Tumor cells develop resistance to chemotherapeutic drugs through multiple mechanisms. Overexpression of efflux transporters is an important source of drug resistance. Efflux transporters such as P-glycoprotein reduce intracellular drug accumulation and compromise drug efficacy. Various nanoparticle-...

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Detalhes bibliográficos
Main Authors: Kirtane, Ameya, Kalscheuer, Stephen, Panyam, Jayanth
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849460/
https://ncbi.nlm.nih.gov/pubmed/24036273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2013.09.001
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