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Exploiting Nanotechnology to Overcome Tumor Drug Resistance: Challenges and Opportunities
Tumor cells develop resistance to chemotherapeutic drugs through multiple mechanisms. Overexpression of efflux transporters is an important source of drug resistance. Efflux transporters such as P-glycoprotein reduce intracellular drug accumulation and compromise drug efficacy. Various nanoparticle-...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3849460/ https://ncbi.nlm.nih.gov/pubmed/24036273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2013.09.001 |
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