Body mass index modifies the relationship between γ-H2AX, a DNA damage biomarker, and pathological complete response in triple-negative breast cancer

BACKGROUND: Body mass index (BMI) is largely investigated as a prognostic and predictive factor in triple-negative breast cancer (TNBC). Overweight and obesity are linked to a variety of pathways regulating tumor-promoting functions, including the DNA damage response (DDR). The DDR physiologically s...

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Udgivet i:BMC Cancer
Main Authors: Barba, Maddalena, Vici, Patrizia, Pizzuti, Laura, Di Lauro, Luigi, Sergi, Domenico, Di Benedetto, Anna, Ercolani, Cristiana, Sperati, Francesca, Terrenato, Irene, Botti, Claudio, Mentuccia, Lucia, Iezzi, Laura, Gamucci, Teresa, Natoli, Clara, Vitale, Ilio, Mottolese, Marcella, De Maria, Ruggero, Maugeri-Saccà, Marcello
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294880/
https://ncbi.nlm.nih.gov/pubmed/28166748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-3045-z
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