Predictive significance of DNA damage and repair biomarkers in triple-negative breast cancer patients treated with neoadjuvant chemotherapy: An exploratory analysis

Response of cancer cells to chemotherapy-induced DNA damage is regulated by the ATM-Chk2 and ATR-Chk1 pathways. We investigated the association between phosphorylated H2AX (γ-H2AX), a marker of DNA double-strand breaks that trigger the ATM-Chk2 cascade, and phosphorylated Chk1 (pChk1), with patholog...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Vici, Patrizia, Benedetto, Anna Di, Ercolani, Cristiana, Pizzuti, Laura, Lauro, Luigi Di, Sergi, Domenico, Sperati, Francesca, Terrenato, Irene, Dattilo, Rosanna, Botti, Claudio, Fabi, Alessandra, Ramieri, Maria Teresa, Mentuccia, Lucia, Marinelli, Camilla, Iezzi, Laura, Gamucci, Teresa, Natoli, Clara, Vitale, Ilio, Barba, Maddalena, Mottolese, Marcella, De Maria, Ruggero, Maugeri-Saccà, Marcello
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767469/
https://ncbi.nlm.nih.gov/pubmed/26544894
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