Predictive significance of DNA damage and repair biomarkers in triple-negative breast cancer patients treated with neoadjuvant chemotherapy: An exploratory analysis

Response of cancer cells to chemotherapy-induced DNA damage is regulated by the ATM-Chk2 and ATR-Chk1 pathways. We investigated the association between phosphorylated H2AX (γ-H2AX), a marker of DNA double-strand breaks that trigger the ATM-Chk2 cascade, and phosphorylated Chk1 (pChk1), with patholog...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Vici, Patrizia, Benedetto, Anna Di, Ercolani, Cristiana, Pizzuti, Laura, Lauro, Luigi Di, Sergi, Domenico, Sperati, Francesca, Terrenato, Irene, Dattilo, Rosanna, Botti, Claudio, Fabi, Alessandra, Ramieri, Maria Teresa, Mentuccia, Lucia, Marinelli, Camilla, Iezzi, Laura, Gamucci, Teresa, Natoli, Clara, Vitale, Ilio, Barba, Maddalena, Mottolese, Marcella, De Maria, Ruggero, Maugeri-Saccà, Marcello
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767469/
https://ncbi.nlm.nih.gov/pubmed/26544894
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