A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA)

The small molecule CADA was shown to down-modulate the expression of human CD4 in a signal peptide-dependent way through inhibition of its cotranslational translocation across the ER membrane. Previous studies characterizing general glycoprotein levels and the expression of 14 different cell surface...

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Bibliographic Details
Published in:Mol Cell Proteomics
Main Authors: Van Puyenbroeck, Victor, Claeys, Elisa, Schols, Dominique, Bell, Thomas W., Vermeire, Kurt
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2017
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294205/
https://ncbi.nlm.nih.gov/pubmed/27998951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M116.061051
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