Syntheses and Anti-HIV and Human Cluster of Differentiation 4 (CD4) Down-Modulating Potencies of Pyridine-Fused Cyclotriazadisulfonamide (CADA) Compounds

CADA compounds selectively down-modulate human cell-surface CD4 protein and are of interest as HIV entry inhibitors and as drugs for asthma, rheumatoid arthritis, diabetes and some cancers. Postulating that fusing a pyridine ring bearing hydrophobic substituents into the macrocyclic scaffold of CADA...

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Publicado no:Bioorg Med Chem
Main Authors: Lumangtad, Liezel A., Claeys, Elisa, Hamal, Sunil, Intasiri, Amarawan, Basrai, Courtney, Yen-Pon, Expedite, Beenfeldt, Davison, Vermeire, Kurt, Bell, Thomas W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7741178/
https://ncbi.nlm.nih.gov/pubmed/33181479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115816
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