Small Molecule Cyclotriazadisulfonamide Abrogates the Upregulation of the Human Receptors CD4 and 4-1BB and Suppresses In Vitro Activation and Proliferation of T Lymphocytes

The small molecule cyclotriazadisulfonamide (CADA) down-modulates the human CD4 receptor, an important factor in T cell activation. Here, we addressed the immunosuppressive potential of CADA using different activation models. CADA inhibited lymphocyte proliferation with low cellular toxicity in a mi...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Claeys, Elisa, Pauwels, Eva, Humblet-Baron, Stephanie, Provinciael, Becky, Schols, Dominique, Waer, Mark, Sprangers, Ben, Vermeire, Kurt
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097030/
https://ncbi.nlm.nih.gov/pubmed/33968048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.650731
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