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Pre-protein signature for full susceptibility to the co-translational translocation inhibitor cyclotriazadisulfonamide (CADA)

Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way. We propose that CADA binds the nascent huCD4 SP in a folded conformation within the translocon resembling a normally transitory state during tran...

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Publicat a:Traffic
Autors principals: Van Puyenbroeck, Victor, Pauwels, Eva, Provinciael, Becky, Bell, Thomas W., Schols, Dominique, Kalies, Kai-Uwe, Hartmann, Enno, Vermeire, Kurt
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980386/
https://ncbi.nlm.nih.gov/pubmed/31675144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12713
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