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Pre-protein signature for full susceptibility to the co-translational translocation inhibitor cyclotriazadisulfonamide (CADA)
Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way. We propose that CADA binds the nascent huCD4 SP in a folded conformation within the translocon resembling a normally transitory state during tran...
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| Publicado no: | Traffic |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6980386/ https://ncbi.nlm.nih.gov/pubmed/31675144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12713 |
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