Signal Peptide-Binding Drug as a Selective Inhibitor of Co-Translational Protein Translocation

In eukaryotic cells, surface expression of most type I transmembrane proteins requires translation and simultaneous insertion of the precursor protein into the endoplasmic reticulum (ER) membrane for subsequent routing to the cell surface. This co-translational translocation pathway is initiated whe...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Vermeire, Kurt, Bell, Thomas W., Van Puyenbroeck, Victor, Giraut, Anne, Noppen, Sam, Liekens, Sandra, Schols, Dominique, Hartmann, Enno, Kalies, Kai-Uwe, Marsh, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4251836/
https://ncbi.nlm.nih.gov/pubmed/25460167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002011
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