Alpha-Lipoic Acid Supplementation Protects Enzymes from Damage by Nitrosative and Oxidative Stress

BACKGROUND: S-nitrosylation of mitochondrial enzymes involved in energy transfer under nitrosative stress may result in ATP deficiency. We investigated whether α-lipoic acid, a powerful antioxidant, could alleviate nitrosative stress by regulating S-nitrosylation, which could result in retaining the...

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Bibliographic Details
Published in:Biochim Biophys Acta
Main Authors: Hiller, Sylvia, DeKroon, Robert, Hamlett, Eric D., Xu, Longquan, Osorio, Cristina, Robinette, Jennifer, Winnik, Witold, Simington, Stephen, Maeda, Nobuyo, Alzate, Oscar, Yi, Xianwen
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293714/
https://ncbi.nlm.nih.gov/pubmed/26344063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2015.09.001
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