Reduced Expression of Lipoic Acid Synthase Accelerates Diabetic Nephropathy

Oxidative stress contributes to the pathogenesis of diabetic nephropathy. In mitochondria, lipoic acid synthase produces α-lipoic acid, an antioxidant and an essential cofactor in α-ketoacid dehydrogenase complexes, which participate in glucose oxidation and ATP generation. Administration of lipoic...

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Hlavní autoři: Yi, Xianwen, Xu, Longquan, Hiller, Sylvia, Kim, Hyung-Suk, Nickeleit, Volker, James, Leighton R., Maeda, Nobuyo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2012
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269922/
https://ncbi.nlm.nih.gov/pubmed/22021711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2011010003
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