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Reduced Expression of Lipoic Acid Synthase Accelerates Diabetic Nephropathy
Oxidative stress contributes to the pathogenesis of diabetic nephropathy. In mitochondria, lipoic acid synthase produces α-lipoic acid, an antioxidant and an essential cofactor in α-ketoacid dehydrogenase complexes, which participate in glucose oxidation and ATP generation. Administration of lipoic...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Nephrology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3269922/ https://ncbi.nlm.nih.gov/pubmed/22021711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2011010003 |
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