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Mice with heterozygous deficiency of lipoic acid synthase have an increased sensitivity to lipopolysaccharide-induced tissue injury

α-Lipoic acid (1, 2-dithiolane-3-pentanoic acid; LA), synthesized in mitochondria by LA synthase (Lias), is a potent antioxidant and a cofactor for metabolic enzyme complexes. In this study, we examined the effect of genetic reduction of LA synthesis on its antioxidant and anti-inflammatory properti...

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Autori principali: Yi, Xianwen, Kim, Kuikwon, Yuan, Weiping, Xu, Longquan, Kim, Hyung-Suk, Homeister, Jonathon W., Key, Nigel S., Maeda, Nobuyo
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Society for Leukocyte Biology 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626770/
https://ncbi.nlm.nih.gov/pubmed/18845616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0308161
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