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Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL(−/−) clear cell renal carcinoma
Most clear cell renal carcinomas (ccRCCs) are initiated by somatic inactivation of the VHL tumor suppressor gene. The VHL gene product, pVHL, is the substrate recognition unit of an ubiquitin ligase that targets the HIF transcription factor for proteasomal degradation; inappropriate expression of HI...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5293026/ https://ncbi.nlm.nih.gov/pubmed/28082722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619726114 |
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