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Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL(−/−) clear cell renal carcinoma

Most clear cell renal carcinomas (ccRCCs) are initiated by somatic inactivation of the VHL tumor suppressor gene. The VHL gene product, pVHL, is the substrate recognition unit of an ubiquitin ligase that targets the HIF transcription factor for proteasomal degradation; inappropriate expression of HI...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Gao, Wenhua, Li, Wei, Xiao, Tengfei, Liu, Xiaole Shirley, Kaelin, William G.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293026/
https://ncbi.nlm.nih.gov/pubmed/28082722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619726114
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