Stromal cues regulate the pancreatic cancer epigenome and metabolome

A fibroinflammatory stromal reaction cooperates with oncogenic signaling to influence pancreatic ductal adenocarcinoma (PDAC) initiation, progression, and therapeutic outcome, yet the mechanistic underpinning of this crosstalk remains poorly understood. Here we show that stromal cues elicit an adapt...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sherman, Mara H., Yu, Ruth T., Tseng, Tiffany W., Sousa, Cristovao M., Liu, Sihao, Truitt, Morgan L., He, Nanhai, Ding, Ning, Liddle, Christopher, Atkins, Annette R., Leblanc, Mathias, Collisson, Eric A., Asara, John M., Kimmelman, Alec C., Downes, Michael, Evans, Ronald M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293019/
https://ncbi.nlm.nih.gov/pubmed/28096419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620164114
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